Our lab is interested in elucidating the cellular and molecular mechanisms of cell development, injury, and repair process of the central nervous system. Specifically, we investigate the mechanisms involved in oligodendrocyte death in white matter injuries, such as multiple sclerosis and cerebral palsy. We use a variety of approaches including primary cell cultures and transgenic and knockout animals to elucidate signal pathways mediating oligodendrocyte injury. The second focus of our laboratory is to develop strategies to promote oligodendrocyte survival and the repair process after injury. These studies should contribute significantly to our understanding of mechanisms of oligodendrocyte development and injury, and uncover new clues for potential prevention and treatment of human white matter diseases.
- VIBS / NRSC 640 – Neurobiology
- VIBS 606 – Neuroanatomical Systems: Neurodegenerative Diseases